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The long-term goal of our research program is to understand molecular mechanisms of signal transduction in normal and pathophysiologic contexts (read more).

News

2021
You can read Vidya's new PROTAC paper here: https://pubs.acs.org/doi/full/10.1021/acs.biochem.1c00377 Summer 2021: Welcome to three new lab members - Dan Jones, Kenna Stenback, and Lauren Litzau (joint student with Andrew Kruse)! Check out Vidys'a paper on phosphoproteome dynamics in response to SHP2 inhibition at https://elifesciences.org/articles/64251 March 1: Congratulations to Katherine Susa for winning a Weintraub Award! This award is presented annually by the University of Washington to recognize outstanding research by graduate students internationally. It is also an oppotunity to highlight her recent paper in Science: https://science.sciencemag.org/content/371/6526/300/tab-article-info. 2020 Check out Katherine's paper on CD81 and its binding partner CD19 here - https://elifesciences.org/articles/52337 February 2020 - Welcome, Lena Tveriakhina, to our Lab!

2019
November: Sanchez's paper "Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling" published in Science Signaling! October: Khal Hentz-Gabriel joins the laboratory. August: Congratulations to Sanchez Jarrett, who successfully defended his dissertation! June: Congratulations to Mark Andrews, lab technician, who left to attend Medical School! April: Drew's manuscript "A Flow-Extension Tethered Particle Motion Assay for Single-Molecule Proteolysis" published in Biochemistry and makes the cover! Julia Rogers Paper "Bispecific Forkhead transcription factor FoxN3 recognizes two distinct motifs with different DNA shapes" published in Molecular Cell! January: Ruili Cao joins the laboratory.